Calorie Restriction Diet can increase Life span
Caloric Restriction (CR) and Life Span
- Reducing food consumption 30-50% (without malnutrition) consistently increases both the mean and maximum life span of laboratory rodents. McCay C.M. et al., 1935, J. Nutr. 10, 63-79; Weindruch & Walford 1988; Masoro E. J. 2005, Mech. Ageing Dev. 126, 913-922.
- CR also opposites the development of diverse age-associated diseases such as cancer, diabetes and renal disease in rodents.
Caloric Restriction (CR) and Aging
vCaloric restriction increases lifespan in several species including C. elegans, yeast, Drosophila, fishes, mice, rats, dogs and monkeys.
vThe decreased intake of total calories appears to be responsible for the increased life span of rodents rather than the reduction in a specific nutrients such as dietary protein or fat.
Inverse Linear Relationship between Caloric Intake and Lifespan in Mice
Anderson, R. A. et al., 2009, Toxicol. Pathol. 37, 47-51.
Fontana, L. et al., 2010, Science 328, 321-326.
CR in Humans
- Long-term CR effects in humans are difficult to conduct due to the difficulties of adhering to the rigorous intervention and the length of the human lifespan.
- The Okinawan population is characterized by the reduced morbidity and mortality, and the high percentage of centenarians in the world lives in this island.
- It has been hypothesized that the long disability-free life expectancy of this population is due to the diet, based on vegetables, grains, soy, fruits, fish and seaweed, and characterized by a low caloric intake (about 20% less than the rest of Japan and 40% less than United States).
- It is noteworthy that this diet is very similar to the caloric restriction interventions designed for experiments in animal models.